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Microscopy with microfluidics in microgravity using FlightScope

Lookup NU author(s): Dr Tom Wareing, Alex Stokes, Kitty Crompton, Dr Koren Murphy, Dr Jack Dawson, Dr Yusuf UgurluogluORCiD, Dr Connor Richardson, Dr Adam WollmanORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

With planned missions to the moon and Mars, it has never been more important to study the impact of microgravity on biological organisms. Parabolic flights are one of the most accessible microgravity research platforms but present challenges: short periods of microgravity and aircraft vibration. Live-imaging is necessary to readout any real-time phenotypes so we developed FlightScope, a new microscopy and microfluidics platform to study dynamic cellular processes in microgravity.

Publication metadata

Author(s): Wareing T, Stokes A, Crompton KE, Murphy K, Dawson J, Ugurluoglu YF, Richardson C, Li H, Prakash M, Wollman AJM

Publication type: Article

Publication status: Published

Journal: npj Microgravity

Year: 2025

Volume: 11

Online publication date: 06/05/2025

Acceptance date: 19/03/2025

Date deposited: 08/05/2025

ISSN (electronic): 2373-8065

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/s41526-025-00470-3

DOI: 10.1038/s41526-025-00470-3

Data Access Statement: Full instructions, designs and CAD files to build Flight-Scope are available here: https://github.com/Alexander-Stokes/Flight-scope. Software to operate Flight-Scope is available here: https://github.com/hongquanli/octopi-research.

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