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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

Lookup NU author(s): Dr Kate HarrisORCiD

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Author(s): Cogswell TJ, Josa-Cullere L, Zimmer D, Galan SRG, Jay-Smith M, Harris KS, Bataille CJR, Jackson TR, Zhang D, Davies SG, Vyas P, Milne TA, Wynne GM, Russell AJ

Publication type: Article

Publication status: Published

Journal: RSC Medicinal Chemistry

Year: 2024

Volume: 15

Issue: 10

Pages: 3495-3506

Print publication date: 01/10/2024

Online publication date: 22/07/2024

Acceptance date: 14/07/2024

Date deposited: 05/04/2025

ISSN (electronic): 2632-8682

Publisher: Royal Society of Chemistry

URL: https://doi.org/10.1039/D4MD00275J

DOI: 10.1039/D4MD00275J

Data Access Statement: The data supporting this article have been included as part of the ESI.

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