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Lookup NU author(s): Dr Lu Wang, Professor John Dark
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2025.Correction to: Nature https://doi.org/10.1038/s41586-023-06311-1 Published online 12 July 2023. In the drug2cell analysis of the initially published article, there was an error in filtering drug and target interactions. The activity (pChEMBL) threshold for these interactions was specifically set for each family of target molecules in accordance with the Illuminating the Druggable Genome (IDG) project. In the original manuscript, there was a discrepancy with the values from the IDG project1. We have now updated the threshold values (“Kinases”: revised from ≤1 μM to ≤30 nM; “GPCRs”: unchanged; “Nuclear hormone receptors”: unchanged; “Ion channels”: unchanged; “others”: revised from ≤30 nM to ≤1 μM) in both the analysis reported here and the drug2cell package (https://github.com/Teichlab/drug2cell, version 0.1.2). The main Fig. 4b, Supplementary Table 9 and the relevant section in Methods (“Drug2cell”) have been revised accordingly. In Fig. 4b, two drugs, irbesartan and zopiclone, have been removed from the original figure due to changes in their target molecules. The main text is unaffected and therefore unchanged.
Author(s): Kanemaru K, Cranley J, Muraro D, Miranda AMA, Ho SY, Wilbrey-Clark A, Patrick Pett J, Polanski K, Richardson L, Litvinukova M, Kumasaka N, Qin Y, Jablonska Z, Semprich CI, Mach L, Dabrowska M, Richoz N, Bolt L, Mamanova L, Kapuge R, Barnett SN, Perera S, Talavera-Lopez C, Mulas I, Mahbubani KT, Tuck L, Wang L, Huang MM, Prete M, Pritchard S, Dark J, Saeb-Parsy K, Patel M, Clatworthy MR, Hubner N, Chowdhury RA, Noseda M, Teichmann SA
Publication type: Note
Publication status: Published
Journal: Nature
Year: 2025
Volume: 640
Print publication date: 10/04/2025
Online publication date: 20/03/2025
Acceptance date: 02/04/2018
ISSN (print): 0028-0836
ISSN (electronic): 1476-4687
Publisher: Nature Research
URL: https://doi.org/10.1038/s41586-025-08886-3
DOI: 10.1038/s41586-025-08886-3
