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Lookup NU author(s): Professor Marloes Peeters, Professor Stephen Rushton
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Copyright © 2025 Chick et al. Campylobacter infections in humans and chickens are a significant burden to health services and the poultry industry. In the UK, over 75% of chicken products are Campylobacter-positive at retail, but the knowledge of the mechanisms responsible for extraintestinal spread into edible tissues remains incomplete. This work aimed to establish if two chicken-associated lineages of Campylobacter jejuni, ST353 and ST464, have the potential for extraintestinal spread. Large- and small-scale chicken colonization trials investigated the infection biology of C. jejuni ST353 (three strains) and ST464 (four strains). Both lineages strongly colonized the ileum and ceca and were detected in liver and spleen. C. jejuni ST353 and ST464 spleen load were significantly increased compared to C. jejuni M1 controls. Immune responses in cecal tonsils exhibited early induction of IFN-γ and suppressed TGFβ at 7 days post-infection with C. jejuni ST464. Histochemistry of gut tissue demonstrated significant decreases in intestinal crypt depth in ileal tissue with increasing severity relative to Campylobacter lineage, M1
Author(s): Chick HM, Williams LK, Sparks N, Khattak F, Vermeij P, Frantzen I, Peeters M, Bijlsma JJE, John D, Ogunrin T, Essex K, Cayrou C, Kanamarlapudi V, Bayliss CD, Ketley JM, Humphrey TJ, Rushton SP, Wilkinson TS
Publication type: Article
Publication status: Published
Journal: Applied and Environmental Microbiology
Year: 2025
Volume: 91
Issue: 3
Print publication date: 19/03/2025
Online publication date: 18/02/2025
Acceptance date: 12/01/2025
Date deposited: 08/04/2025
ISSN (print): 0099-2240
ISSN (electronic): 1098-5336
Publisher: American Society for Microbiology
URL: https://doi.org/10.1128/aem.01614-24
DOI: 10.1128/aem.01614-24
PubMed id: 39964091
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