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Heart Transplantation and Donation After Circulatory Death in Children. A Review of the Technological, Logistical and Ethical Framework

Lookup NU author(s): Dr Louise Kenny, Professor John Dark, Mohamed Nassar, Dr Emma Simpson

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Copyright © 2025 Kenny, Armstrong, Berman, Brierley, Crossland, Dark, Gardiner, Large, Manas, Nassar, Shaw and Simpson.Heart transplant for adults following Donation after Circulatory Death (DCD) is well established in many parts of the world, including the United Kingdom (UK). Small child DCD hearts have now been recovered in the UK and internationally utilising novel technologies. Despite these recent advances, extension of this practice to pediatric cardiac transplantation has been slow and difficult despite the severe shortage of donors for children leading to a high number of deaths annually of children waiting for heart transplant. This is in direct contrast with the thriving UK programme of adult DCD heart transplant and pediatric DCD donation for non-cardiac organs. There has been insufficient action in addressing this inequality thus far. Barriers to development of a pediatric cardiac DCD programme are multifaceted: ethical concerns, technological paucity, financial and logistical hurdles. We describe the background, live issues, current developments and how we are driving resources toward a sustainable DCD programme for small children in the UK to provide valuable insights to other countries of the elements and principles at play. This is a call to responsible bodies to take urgent and achievable actions to establish an equitable paediatric DCD cardiac programme for donors, recipients and their families.


Publication metadata

Author(s): Kenny LA, Armstrong L, Berman M, Brierley J, Crossland D, Dark J, Gardiner D, Large SR, Manas D, Nassar M, Shaw D, Simpson E

Publication type: Review

Publication status: Published

Journal: Transplant International

Year: 2025

Volume: 38

Print publication date: 01/02/2025

Online publication date: 14/02/2025

Acceptance date: 23/01/2025

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

Publisher: Frontiers Media SA

URL: https://doi.org/10.3389/ti.2025.13801

DOI: 10.3389/ti.2025.13801

PubMed id: 40026599


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