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Women and People From Deprived Areas Are Less Likely to be Assessed for Liver Transplantation for Alcohol-related Liver Disease: Results From a National Study of Transplant Assessments

Lookup NU author(s): Dr Steven MassonORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).

Abstract

Copyright © 2025 The Author(s).Background. Alcohol-related liver disease (ArLD) is the most common indication for liver transplantation in Europe and the United States. Few studies have examined the characteristics of patients with ArLD formally assessed for liver transplants. Methods. We collected prospective data on every patient with ArLD formally assessed for liver transplantation in the United Kingdom during a 12-mo period. Results. Five hundred forty-nine patients with ArLD were assessed for liver transplantation. The median Model for End-Stage Liver Disease (MELD) score was 15 and the UK MELD score was 54. 24% were women. The median duration of abstinence was 12 mo. Listing outcomes were 59% listed, 4% deferred, and 37% not listed. The reasons for not listing were medical comorbidities (29%), too early for transplantation (20%), potential recoverability (18%), recent alcohol use (12%), and other (21%). Patients listed for transplant had a higher median MELD (16 versus 13; P < 0.001) and UK MELD scores (55 versus 53; P < 0.001), longer duration of abstinence (median 12 versus 10 mo; P = 0.026), and no differences in sex (P = 0.258), age distribution (P = 0.53), or deprivation deciles compared with those not listed. Comparing patients assessed for transplantation to national data on deaths from ArLD revealed a lower proportion of female patients (24% assessed versus 36% deaths; P < 0.001) and patients from areas of high deprivation (assessments: deaths, most deprived decile 1:20 versus least deprived decile 1:9). Conclusions. This study provides the first complete national profile of evaluations for liver transplantation for patients with ArLD. Women and patients from the most deprived deciles of the population may be relatively underrepresented.

Publication metadata

Author(s): Oldroyd C, Aluvihare V, Holt A, Chew Y, Masson S, Parker R, Rajoriya N, Ryan J, Shepherd L, Simpson K, Wai C, Webzell I, Walton S, Verne J, Allison MED

Publication type: Article

Publication status: Published

Journal: Transplantation Direct

Year: 2025

Volume: 11

Issue: 3

Print publication date: 01/03/2025

Acceptance date: 05/11/2024

Date deposited: 24/02/2025

ISSN (electronic): 2373-8731

Publisher: Lippincott, Williams & Wilkins

URL: https://doi.org/10.1097/TXD.0000000000001761

DOI: 10.1097/TXD.0000000000001761

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