Browse by author
Lookup NU author(s): Dr Mark EldridgeORCiD
This is the final published version of an article that has been published in its final definitive form by eLife Sciences Publications Ltd, 2023.
For re-use rights please refer to the publisher's terms and conditions.
Decades of neuroscientific research has sought to understand medial temporal lobe (MTL) involvement in perception. Apparent inconsistencies in the literature have led to competing interpretations of the available evidence; critically, findings from human participants with naturally occurring MTL damage appear to be inconsistent with data from monkeys with surgical lesions. Here, we leverage a 'stimulus-computable' proxy for the primate ventral visual stream (VVS), which enables us to formally evaluate perceptual demands across stimulus sets, experiments, and species. With this modeling framework, we analyze a series of experiments administered to monkeys with surgical, bilateral damage to perirhinal cortex (PRC), an MTL structure implicated in visual object perception. Across experiments, PRC-lesioned subjects showed no impairment on perceptual tasks; this originally led us(Eldridge et al., 2018) to conclude that PRC is not involved in perception. Here, we find that a 'VVS-like' model predicts both PRC-intact and -lesioned choice behaviors, suggesting that a linear readout of the VVS should be sufficient for performance on these tasks. Evaluating these computational results alongside findings from human experiments, we suggest that results from (Eldridge et al., 2018) alone cannot be used as evidence against PRC involvement in perception. These data indicate that experimental findings from human and non-human primates are consistent. As such, what appeared to be discrepancies between species was in fact due to reliance on informal accounts of perceptual processing.
Author(s): Bonnen T, Eldridge MAG
Publication type: Article
Publication status: Published
Journal: eLife
Year: 2023
Volume: 12
Online publication date: 06/06/2023
Acceptance date: 05/06/2023
Date deposited: 19/02/2025
ISSN (electronic): 2050-084X
Publisher: eLife Sciences Publications Ltd
URL: https://doi.org/10.7554/eLife.84357
DOI: 10.7554/eLife.84357
Data Access Statement: All scripts used for analysis and visualization can be accessed via github at https://github.com/tzler/eldridge_reanalysis (copy archived at Bonnen, 2023). All stimuli and behavioral data used in these analyses can be downloaded via Dryad at https://doi.org/10.5061/dryad.r4xgxd2h7
PubMed id: 37278517
Altmetrics provided by Altmetric
