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PET reporter systems for the brain

Lookup NU author(s): Dr Mark EldridgeORCiD

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Abstract

© 2023. Positron emission tomography (PET) can be used as a noninvasive method to longitudinally monitor and quantify the expression of proteins in the brain in vivo. It can be used to monitor changes in biomarkers of mental health disorders, and to assess therapeutic interventions such as stem cell and molecular genetic therapies. The utility of PET monitoring depends on the availability of a radiotracer with good central nervous system (CNS) penetration and high selectivity for the target protein. This review evaluates existing methods for the visualization of reporter proteins and/or protein function using PET imaging, focusing on engineered systems, and discusses possible approaches for future success in the development of high-sensitivity and high-specificity PET reporter systems for the brain.

Publication metadata

Author(s): Nerella SG, Michaelides M, Minamimoto T, Innis RB, Pike VW, Eldridge MAG

Publication type: Review

Publication status: Published

Journal: Trends in Neurosciences

Year: 2023

Volume: 46

Issue: 11

Pages: 941-952

Print publication date: 01/11/2023

Online publication date: 19/09/2023

Acceptance date: 02/04/2018

ISSN (print): 0166-2236

ISSN (electronic): 1878-108X

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.tins.2023.08.007

DOI: 10.1016/j.tins.2023.08.007

PubMed id: 37734962

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