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Lookup NU author(s): Dr Mark EldridgeORCiD
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Not subject to U.S. Copyright. Published 2025 by American Chemical Society.Gene therapy and cell transduction are gaining interest as therapeutic strategies for neurological and psychiatric disorders. Positron emission tomography (PET) has been established as a uniquely powerful modality for brain molecular imaging in vivo. The utility of PET depends on the development and application of suitably specific radiotracers and/or reporter probes. PET probes are potentially useful to confirm the success of gene therapy or cell transduction without the need for brain biopsy or necroscopy. Probes are needed to target proteins expressed by specific exogenous transgenes or cells and could play a crucial role in elucidating neurobiological mechanisms and in longitudinal tracking of expression for therapeutic applications. This perspective article describes the current status and ongoing challenges for the design and development of PET reporter probes for verifying the expression of reporter genes and cells in the brain. Radiochemical aspects, applications, and translational challenges for diagnostic and therapeutic interventions are highlighted.
Author(s): Nerella SG, Eldridge MAG, Innis RB, Pike VW
Publication type: Review
Publication status: Published
Journal: Journal of Medicinal Chemistry
Year: 2025
Volume: 68
Issue: 3
Pages: 2198–2218
Print publication date: 13/02/2025
Online publication date: 29/01/2025
Acceptance date: 15/01/2025
ISSN (print): 0022-2623
ISSN (electronic): 1520-4804
Publisher: American Chemical Society
URL: https://doi.org/10.1021/acs.jmedchem.4c02326
DOI: 10.1021/acs.jmedchem.4c02326
