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Different applications and differentiated libraries for crystallographic fragment screening

Lookup NU author(s): Dr Jessica WattORCiD, Dr Mathew Martin, Professor Jane Endicott, Professor Martin NobleORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024 The AuthorsMacromolecular X-ray crystallography allows detection and characterisation of the binding of small, low-affinity chemical fragments. Here we review the utility of fragment screening for drug discovery, its potential for use in discovery science, as well as some of the distinct types of fragments that have been compiled into libraries.

Publication metadata

Author(s): Watt J, Martin MP, Endicott JA, Noble MEM

Publication type: Review

Publication status: Published

Journal: Current Opinion in Structural Biology

Year: 2025

Volume: 90

Print publication date: 01/02/2025

Online publication date: 18/01/2025

Acceptance date: 24/12/2024

ISSN (print): 0959-440X

ISSN (electronic): 1879-033X

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.sbi.2024.102982

DOI: 10.1016/j.sbi.2024.102982

Data Access Statement: No data was used for the research described in the article.

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