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Lookup NU author(s): Dr Meher Lad, Professor Tim GriffithsORCiD, Professor John-Paul TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. BACKGROUND: Hearing loss is associated with cognitive and neuroimaging markers of Alzheimer's disease dementia but it is unclear how specific measures relate to these after accounting for a range of hearing abilities. METHOD: 200 participants (155 cognitively normal, 25 mild cognitively impaired and 20 Alzheimer's disease dementia) underwent auditory testing (peripheral and central abilities), cognitive testing and MR scanning (structural and diffusion-weighted sequences) to evaluate the relationship between hearing, cognition and imaging brain measures. RESULT: Central auditory measures such as speech-in-noise perception and auditory memory for longer durations were associated with cognitive impairment across the Alzheimer's disease continuum and specific auditory measures were independently associated with morphometric and diffusion-weighted brain measures. CONCLUSION: Auditory cognition could serve as a unique marker of cognition in Alzheimer's disease dementia and reflects imaging-derived brain changes potentially related to neurodegeneration.
Author(s): Lad M, Griffiths T, Taylor J-P
Publication type: Article
Publication status: Published
Journal: Alzheimer's & Dementia
Year: 2024
Volume: 20
Issue: S3
Print publication date: 01/12/2024
Online publication date: 03/01/2025
Acceptance date: 02/04/2018
Date deposited: 21/01/2025
ISSN (print): 1552-5260
ISSN (electronic): 1552-5279
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/alz.089753
DOI: 10.1002/alz.089753
PubMed id: 39750436
Notes: Supplement: Clinical Manifestations
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