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Lookup NU author(s): Dr Chloe HinchliffeORCiD, Victoria Macrae, Professor Fai NgORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2025.Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. Wearable sensors, like inertial measurement units (IMUs), offer a way to monitor daily activities and evaluate functional capacity. This study investigates the relationship between sit-to-stand and stand-to-sit transitions and self-reported physical and mental fatigue in participants with Parkinson’s, Huntington’s, rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren’s syndrome and inflammatory bowel disease. Over 4 weeks, participants wore an IMU and reported fatigue levels four times daily. Using mixed-effects models, associations were identified between fatigue and specific kinematic features, such as 5th and 95th percentiles of sit-to-stand performance, suggesting that fatigue alters the control and effort of movement. These kinematic features show promise as indicators for fatigue in these patient populations.
Author(s): Romijnders R, Atrsaei A, Rehman RZU, Strehlow L, Massoud J, Hinchliffe C, Macrae V, Emmert K, Reilmann R, van der Woude CJ, Van Gassen G, Baribaud F, Ahmaniemi T, Chatterjee M, Vitturi BK, Pinaud C, Kalifa J, Avey S, Ng W-F, Hansen C, Manyakov NV, Maetzler W
Publication type: Article
Publication status: Published
Journal: npj Digital Medicine
Year: 2025
Volume: 8
Issue: 1
Online publication date: 06/01/2025
Acceptance date: 11/12/2024
Date deposited: 20/01/2025
ISSN (electronic): 2398-6352
Publisher: Nature Research
URL: https://doi.org/10.1038/s41746-024-01386-0
DOI: 10.1038/s41746-024-01386-0
Data Access Statement: The data for this study are available from the corresponding author upon reasonable request.
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