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Establishing Minimal Clinically Important Differences for the Cognitive and Linguistic Scale (CALS) in Pediatric Neurorehabilitation

Lookup NU author(s): Dr Rob ForsythORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

The Cognitive and Linguistic Scale (CALS) was developed to serially monitor cognitive recovery of children and young people after severe acquired brain injury (ABI) during inpatient rehabilitation. The CALS can be used to derive Cognitive Ability Estimates (CAE) which are Rasch-propertied (unidimensional, interval-scale) and therefore may be ideally applied for use in research including within the context of clinical trials. Here, we used established statistical distribution-based and expert consensus-based methods to estimate the Minimal Clinically Important Difference (MCID) for CAE derived from the CALS. Together, results suggest a MCID of approximately 4-7 CAE units. These data can be used to aid in the design and interpretation of clinical studies proposing to use the CALS CAE as an outcome measure.

Publication metadata

Author(s): Svingos AM, Forsyth RJ, Alkhoury L, Slomine BS, Suskauer SJ, Watson WD, Blackwell LS, Shah SA

Publication type: Article

Publication status: Published

Journal: Archives of Physical Medicine and Rehabilitation

Year: 2025

Pages: epub ahead of print

Online publication date: 06/01/2025

Acceptance date: 24/12/2024

Date deposited: 31/12/2024

ISSN (print): 0003-9993

ISSN (electronic): 1532-821X

Publisher: Elsevier

URL: https://doi.org/10.1016/j.apmr.2024.12.020

DOI: 10.1016/j.apmr.2024.12.020

ePrints DOI: 10.57711/bd12-kc31

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