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Lookup NU author(s): Vyte Janiukstyte, Csaba Kozma, Dr Tom Owen, Professor Yujiang WangORCiD, Professor Peter TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). EEG slowing is reported in various neurological disorders including Alzheimer's, Parkinson's and Epilepsy. Here, we investigate alpha rhythm slowing in individuals with refractory temporal lobe epilepsy compared with healthy controls, using scalp EEG and magnetoencephalography. We retrospectively analysed data from 17 (46) healthy controls and 22 (24) individuals with temporal lobe epilepsy who underwent scalp EEG and magnetoencephalography recordings as part of presurgical evaluation. Resting-state, eyes-closed recordings were source reconstructed using the standardized low-resolution brain electrographic tomography method. We extracted slow 6-9Hz and fast 10-11Hz alpha relative band power and calculated the alpha power ratio by dividing slow alpha by fast alpha. This ratio was computed for all brain regions in all individuals. Alpha oscillations were slower in individuals with temporal lobe epilepsy than controls (P<0.05). This effect was present in both the ipsilateral and contralateral hemispheres and across widespread brain regions. Alpha slowing in temporal lobe epilepsy was found in both EEG and magnetoencephalography recordings. We interpret greater slow alpha as greater deviation from health.
Author(s): Janiukstyte V, Kozma C, Owen TW, Chaudhary UJ, Diehl B, Lemieux L, Duncan JS, Rugg-Gunn F, De Tisi J, Wang Y, Taylor PN
Publication type: Article
Publication status: Published
Journal: Brain Communications
Year: 2024
Volume: 6
Issue: 6
Online publication date: 05/12/2024
Acceptance date: 03/12/2024
Date deposited: 08/01/2025
ISSN (electronic): 2632-1297
Publisher: Oxford University Press
URL: https://doi.org/10.1093/braincomms/fcae439
DOI: 10.1093/braincomms/fcae439
Data Access Statement: Data and code to reproduce the main findings of the study are available here: https://zenodo.org/records/13171578
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