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Lookup NU author(s): Dr Prakash Kannan Loganathan, Dr Vrinda Nair
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© 2023 The Author(s). Published by Oxford University Press on behalf of the Canadian Paediatric Society. All rights reserved. Objectives: To determine oxygen saturation (SpO2) values and their variability in healthy-term neonates at high altitude. Methods: In a prospective multisite, non-randomized blinded study, we performed SpO2 measurements in healthy neonates admitted to postnatal wards and followed up in Public Health Nurse Clinics (PHNC) in Calgary, Alberta, Canada. We recruited healthy-term neonates (≥37 weeks) between 6 and 24 h of age. Neonates underwent simultaneous pre- and post-ductal SpO2 recordings every 12 to 24 h until hospital discharge and again in the PHNC within a few days after discharge. Neonates were followed for 8 weeks to ascertain their health status. Results: We included data for 252 neonates in hospital and 105 neonates presenting to the PHNC for follow-up. In hospital, the mean pre- and post-ductal SpO2 were 94.3% and 96.0%, respectively. In the PHNC, mean pre- and post-ductal SpO2 were 94.4% and 95.6%, respectively. Desaturation episodes occurred frequently at a median rate of once every 5 minutes. The median duration of pre-ductal desaturation episodes was longer in hospital than in the PHNC for all SpO2 thresholds (P < 0.05). Conclusion: SpO2 levels in healthy-term neonates at high altitude are approximately 94% and remained stable over the first few days after birth. Desaturation episodes are common in the immediate neonatal period, but their duration decreases over time, and they are not associated with clinical deterioration.
Author(s): Kannan Loganathan P, Netel-Aguirre A, Lodha A, Awad EA, Fajardo C, Nair V, Scotland J, Singhal N, Young M, York K, Rabi Y
Publication type: Article
Publication status: Published
Journal: Paediatrics and Child Health
Year: 2024
Volume: 29
Issue: 7
Pages: 422-428
Print publication date: 01/11/2024
Online publication date: 24/11/2023
Acceptance date: 13/10/2023
ISSN (print): 1205-7088
ISSN (electronic): 1918-1485
Publisher: Oxford University Press
URL: https://doi.org/10.1093/pch/pxad072
DOI: 10.1093/pch/pxad072
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