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Lookup NU author(s): Sola AkinboladeORCiD, Ross FairbairnORCiD, Alex InskipORCiD, Rhiannon PotterORCiD, Aoife Oliver, Professor Dawn CraigORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. Medicine repurposing is a strategy to identify new uses for the existing medicines for the purpose of addressing areas of unmet medical need. This paper aims to provide horizon scanning intelligence on repurposed medicines that are evaluated by non-commercial organizations such as academia and highlights opportunities for further research to improve patient health outcomes. A scan of the clinical landscape of non-commercially sponsored repurposed medicines is routinely conducted by the NIHR Innovation Observatory (IO). This ongoing project involves a horizon scan of clinical trial registries and the IO's internal horizon scanning Medicines Innovation Database to identify potential candidate medicines used as monotherapy or in combination to treat new indications outside the scope of their licensed indication. In addition to making these data publicly available, the output also supports the NHS England Medicines Repurposing Programme. The snapshot scan reported here (trials completing April 2020–March 2023) identified a total of 528 technologies (meaning, a single product or combination of medicinal products targeting a specific indication in one or more related trials). The technologies were classified according to their characteristics and targeted therapeutic indications as well as revealing the least treated disease conditions. The candidate medicines identified in this scan could potentially receive tailored support toward adoption into practice and policy. The NIHR IO regularly provides this scan as a source of intelligence on repurposed medicines. This provides valuable insights into innovation trends, gaps, and areas of unmet clinical need.
Author(s): Akinbolade S, Fairbairn R, Inskip A, Potter R, Oliver A, Craig D
Publication type: Article
Publication status: Published
Journal: Pharmacology Research and Perspectives
Year: 2025
Volume: 13
Issue: 1
Print publication date: 01/02/2025
Online publication date: 16/12/2024
Acceptance date: 25/11/2024
Date deposited: 07/01/2025
ISSN (electronic): 2052-1707
Publisher: John Wiley & Sons Ltd
URL: https://doi.org/10.1002/prp2.70049
DOI: 10.1002/prp2.70049
Data Access Statement: The data that support the findings of this study are openly available on the NIHR Innovation Observatory website at https://io.nihr.ac.uk/news/dashboardpages/repurposed-medicines-dashboard/, reference number 15.
PubMed id: 39686549
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