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Lookup NU author(s): Dr Charlotte CurrieORCiD, Dr Emma Spoor
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Copyright © 2024 by the International Society of Gynecological Pathologists. Human papillomavirus (HPV)-associated multiphenotypic sinonasal carcinoma is a rare and recently described epithelial neoplasm exhibiting myoepithelial differentiation and morphological overlap with salivary gland neoplasms, especially adenoid cystic carcinoma; it is commonly associated with HPV, especially type 33. It has mainly been reported in the nasal cavity and paranasal sinuses with a single case reported in the breast. Herein, we report the first vulval example in a 47-year-old patient who presented with a large craggy mass in the region of the Bartholin gland. The histologic features were of a high-grade carcinoma composed of basaloid cells arranged in sheets and nests, with occasional ductal formations, surrounded by densely hyalinised basement membrane-type material. There was diffuse block-type immunoreactivity with p16 and HPV genotyping revealed high-risk HPV type 16. In reporting this case, we highlight the propensity for "salivary gland-type" neoplasms to arise in the vulva, especially in the Bartholin gland, and stress that pathologists should consider salivary-type neoplasms when faced with a morphologically unusual vulval tumor.
Author(s): Currie CC, Leaning D, McCluggage WG, Spoor E
Publication type: Article
Publication status: Published
Journal: International Journal of Gynecological Pathology
Year: 2025
Volume: 44
Issue: 1
Pages: 37-41
Print publication date: 01/01/2025
Acceptance date: 02/04/2018
Date deposited: 13/02/2025
ISSN (print): 0277-1691
ISSN (electronic): 1538-7151
Publisher: Lippincott Williams & Wilkins
URL: https://doi.org/10.1097/PGP.0000000000001034
DOI: 10.1097/PGP.0000000000001034
PubMed id: 38661560
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