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Lookup NU author(s): Emeritus Professor David Brooks, Professor Nicola PaveseORCiD
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© Springer-Verlag GmbH Germany, part of Springer Nature 2024. Isolated rapid-eye-movement sleep behavior disorder (iRBD) is a strong predictor of Parkinson’s disease and Dementia with Lewy bodies. Previous studies indicate that cortical atrophy in iRBD patients may be linked to cognitive impairment, but the pattern of atrophy is inconsistently reported. This study aimed to elucidate cortical atrophy patterns in a cognitively unimpaired iRBD cohort, focusing on regions associated with cognitive functions, particularly the cuneus/precuneus, and evaluated the predictive value for future phenoconversion. We conducted voxel-based morphometry and region of interest (ROI) analysis of structural MRI scans of 36 healthy controls and 19 iRBD patients, nine of whom also received a 3-year follow-up MRI scan. The iRBD patients were followed clinically for 8 years, and time-to-event analyses, using Cox regression, were performed based on baseline ROI volumes. The iRBD patients had lower gray-matter volume in the cuneus/precuneus region as well as in subcortical structures (caudate nuclei and putamen) compared to controls. Eight iRBD patients developed either Parkinson’s disease (N = 4) or Dementia with Lewy bodies (N = 4) during the follow-up period. Time-to-event analyses showed that lower right cuneus volume was associated with a higher risk of phenoconversion to alpha-synuclein-linked Parkinsonism in the iRBD patients (Hazard ratio = 13.0, CI: 1.53–110), and correlated with shorter time to conversion. In addition, lower volumes of the bilateral precuneus trended to indicate a higher risk of phenoconversion. These findings suggest a potential predictive value of cuneus and precuneus volumes in identifying iRBD patients at risk of disease progression, even before the onset of cognitive impairment.
Author(s): Baun AM, Iranzo A, Terkelsen MH, Stokholm MG, Staer K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Santamaria J, Moller A, Gaig C, Brooks DJ, Borghammer P, Tolosa E, Eskildsen SF, Pavese N
Publication type: Note
Publication status: Published
Journal: Journal of Neurology
Year: 2025
Volume: 272
Online publication date: 16/12/2024
Acceptance date: 27/10/2024
ISSN (print): 0340-5354
ISSN (electronic): 1432-1459
Publisher: Springer Science and Business Media Deutschland GmbH
URL: https://doi.org/10.1007/s00415-024-12762-x
DOI: 10.1007/s00415-024-12762-x
PubMed id: 39680182
