Browse by author
Lookup NU author(s): Amar Rajgor, James O'HaraORCiD, David Hamilton, Sarah Hill
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Clinical Otolaryngology published by John Wiley & Sons Ltd.Introduction: Historically, 15% of laryngeal cancer patients undergo non-curative management, but pragmatic data on this group are limited. This information is crucial to help patients make informed decisions about their care. Supported by the Northern Head & Neck Alliance, this retrospective study is the first to present survival outcomes for non-curative laryngeal cancer patients in Northern UK. Methods: Retrospective data were compiled for patients with laryngeal squamous cell cancer from five large tertiary head and neck centres in Northern UK (Newcastle, Glasgow, Sheffield, Leeds, and Middlesbrough). The collected data encompassed demographic details, treatment and clinical outcomes. Results: Among 373 patients, the mean age was 72, and 73% were male. The median follow-up was 6 months. 17% had early-stage (T1-2), and 83% had late-stage (T3-4) disease. By data collection, 99% had died. The mean survival time (MST) was 9.1 months. Patients with metastases had an MST of 6.9 months, while those without had 9.4 months. Early-stage patients had an MST of 13.3 months, compared to 8.2 months for advanced disease. By subsite, MSTs were 8.2 months for supraglottic, 12.5 for glottic, 5.5 for subglottic, and 7.9 for transglottic cancers. Conclusion: This study stands as the first to explore survival outcomes in laryngeal cancer patients undergoing non-curative management. The findings can provide valuable insights for informing patients about survival in the absence of radical treatment, facilitating important decision-making conversations.
Author(s): Rajgor A, Hurley R, Douglas CM, Paterson C, Moor J, Lester S, Sionis S, Davies K, O'Hara J, Inman G, Jones T, Hamilton DW, Hill S, O'Neill S, McLoughlin A, Jose J, Wong W, Ho M, Horne D, Homer J, Kennedy M, Kinloch E, Metcalf R, Varley I, Carroll T, Healy S, Cocks H, Nugent M, Vassilou L, Kyzas P, Greenman J, Schache A, Fleming J, Patterson J, Hunter K, Parvulescu P, Brooker R, Shaw R, Meysner S, Rominiyi O, Mandrik O
Publication type: Article
Publication status: Published
Journal: Clinical Otolaryngology
Year: 2025
Pages: epub ahead of print
Online publication date: 11/12/2024
Acceptance date: 08/11/2024
Date deposited: 07/01/2025
ISSN (print): 1749-4478
ISSN (electronic): 1749-4486
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/coa.14260
DOI: 10.1111/coa.14260
Data Access Statement: Data are available on request from authors.
Altmetrics provided by Altmetric
