Browse by author
Lookup NU author(s): Dr Salman Razvi
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Context: Subclinical thyroid dysfunction (ScTD) comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) has been associated with increased risk for cardiovascular events.Objective: To assess associations between ScTD and cardiovascular risk factors (cvRFs) according to age and sex.Design and setting: Pooled individual participant data analysis of large prospective cohort studies from the Thyroid Studies Collaboration.Participants: Aged 18 to 103 years with SHypo (TSH >4.50 mU/l, normal fT4) and SHyper (TSH <0.45 mU/l, normal fT4) vs. euthyroid (TSH 0.45-4.50 mU/l).Interventions: None as this is an observational study.Main outcome measures: cvRFs, i.e. blood pressure, lipid levels, hs-CRP.Results: Of 69,006 participants (mean age 62 years, 55% women, 25% current smokers) from 16 international cohorts, 3,748 (5.4%) had SHypo and 3,428 (5.0%) had SHyper. In both women and men, systolic and diastolic BP were similar regardless of thyroid status. Exceptions were lower diastolic BP in women with SHyper compared to euthyroids (adjusted mean difference [aMD] -1.3 mmHg, 95%CI -2.0 to -0.5), and lower systolic BP in men with SHyper compared to euthyroids (aMD -3.1 mmHg, 95%CI -4.8 to-1.4). In both women and men, lipid levels (total, HDL, LDL cholesterol, triglycerides) and hs-CRP were similar regardless of thyroid status. The only exception were women with SHyper who had a lower LDL cholesterol compared to euthyroids (aMD -0.17 mmol/l, 95%CI -0.29 to -0.05).Conclusions: Participants with ScTD and euthyroids have similar cvRFs and differences are arguably too small to explain the increased cardiovascular risk in ScTD observed in previous studies.
Author(s): Baretella O, Blum MR, Abolhassani N, Alwan H, Wildisen L, Del Giovane C, Tal K, Moutzouri E, Åsvold BO, Cappola AR, Gussekloo J, Iacoviello M, Iervasi G, Imaizumi M, Weiler S, Razvi S, Sgarbi JA, Völzke H, Brown SJ, Walsh JP, Vaes B, Yeap BB, Dullaart RPF, Bakker SJL, Kavousi M, Ceresini G, Ferrucci L, Aujesky D, Peeters RP, Bauer DC, Feller M, Rodondi N
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Endocrinology and Metabolism
Year: 2024
Issue: ePub ahead of Print
Online publication date: 12/12/2024
Acceptance date: 12/12/2024
Date deposited: 17/12/2024
ISSN (print): 0021-972X
ISSN (electronic): 1945-7197
Publisher: Oxford University Press
URL: https://doi.org/10.1210/clinem/dgae860
DOI: 10.1210/clinem/dgae860
Data Access Statement: Restrictions apply to the availability of some or all data generated or analyzed during this study to preserve patient confidentiality or because they were used under license. The corresponding author will on request detail the restrictions and any conditions under which access to some data may be provided
PubMed id: 39667018
Altmetrics provided by Altmetric
