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Lookup NU author(s): Professor John-Paul TaylorORCiD, Dr Christopher Morris, Dr David Cousins, Professor Mark BakerORCiD, Dr Stella Paddick
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2024.The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.
Author(s): Wood GK, Sargent BF, Ahmad Z-U-A, Tharmaratnam K, Dunai C, Egbe FN, Martin NH, Facer B, Pendered SL, Rogers HC, Hubel C, van Wamelen DJ, Bethlehem RAI, Giunchiglia V, Hellyer PJ, Kalsi G, Needham E, Easton A, Jackson TA, Cunningham C, Upthegrove R, Pollak TA, Hotopf M, Solomon T, Pett SL, Shaw PJ, Wood N, Harrison NA, Miller KL, Jezzard P, Williams G, Duff EP, Williams S, Zelaya F, Smith SM, Keller S, Broome M, Kingston N, Husain M, Vincent A, Bradley J, Chinnery P, Menon DK, Aggleton JP, Nicholson TR, Taylor J-P, David AS, Carson A, Bullmore E, Breen G, Hampshire A, Zandi MS, Wong SH, Williams G, van Wamelen DJ, Venneri A, Veenith T, Underwood J, Ahmad Z-U-A, Trender W, Trender W, Thomson E, Thomas RH, Tamborska A, Taams L, Smith SM, Smith J, Smith CJ, Singh B, Sieradzki A, Shil RSK, Semple S, Seed AW, Sawcer SJ, Sargent BF, Samuel M, Salman RA-S, Rota S, Roberts A, Pollak TA, Peacock S, Patel A, Palmos A, Ostermann M, Orazulume O, O'Malley R, Nicholas N, Newcombe V, Nair A, Mulholland C, Morris CM, Monssen D, McIntosh AM, McIlwaine R, McKeever S, McGlinchey E, McDonnell G, Martin N, Mansoori P, Madarshahian D, MacIver CL, Lunn MP, Lilleker JB, Lewis G, Kyaw S, Zvrskovec JK, Jenkins TM, Irani S, Hughes S, Huang Y, Holland AE, Hodel EM, Hiscox J, Hilton O, Hetherington C, Hartmann M, Harrison PJ, Harrison E, Harris JD, Hardwick M, Hamid SHM, Gunatilake S, Grundmann A, Grimbly V, Griffiths M, Gregory R, Glen K, George L, Garjani A, Galea I, Francis R, Fernandes PM, Evangelou N, Ellul MA, Duff E, Dregan A, Dodd KC, Defres S, Davies N, Darby A, Cousins D, Cossette N, Collie C, Coles A, Coleman JRI, Christmas DM, Christmas D, Cavanagh J, Castell H, Butler M, Broome M, Breuer J, Breen DP, Bradley J, Boardman SA, Blackledge B, Berry A, Benjamin L, Batra R, Basu N, Barrett S, Baker MR, Armour C, Amin J, Allen CM, Al-Chalabi A, Alam AM, Michael BD, Paddick S-M, Leek EC
Publication type: Article
Publication status: Published
Journal: Nature Medicine
Year: 2024
Pages: epub ahead of print
Online publication date: 23/09/2024
Acceptance date: 18/09/2024
Date deposited: 25/11/2024
ISSN (print): 1078-8956
ISSN (electronic): 1546-170X
Publisher: Nature Research
URL: https://doi.org/10.1038/s41591-024-03309-8
DOI: 10.1038/s41591-024-03309-8
PubMed id: 39312956
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