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Lookup NU author(s): Claire Schwab, Emerita Professor Christine Harrison
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.Children diagnosed with acute myeloid leukaemia (paediatric AML [pAML]) have limited treatment options and relapse rates due to chemoresistance and refractory disease are over 30%. Current treatment is cytotoxic and in itself has long-lasting harsh side effects. New, less toxic treatments are needed. The bone marrow microenvironment provides chemoprotection to leukaemic cells through cell communication and interaction with mesenchymal stem cells (MSCs), but this is not well defined in pAML. Using primary patient material, we identify a cell contact-independent mechanism of MSC-mediated chemoprotection involving extrinsic soluble factors that is abrogated through inhibition of the JAK/STAT and ERK pathways.
Author(s): Laing A, Elmarghany A, Alghaith AA, Gouma A, Stevens T, Winton A, Cassels J, Clarke CJ, Schwab C, Harrison CJ, Gibson B, Keeshan K
Publication type: Article
Publication status: Published
Journal: British Journal of Haematology
Year: 2024
Pages: epub ahead of print
Online publication date: 10/11/2024
Acceptance date: 28/10/2024
Date deposited: 25/11/2024
ISSN (print): 0007-1048
ISSN (electronic): 1365-2141
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/bjh.19884
DOI: 10.1111/bjh.19884
Data Access Statement: The RNA-seq data discussed in this publication have been deposited in the GEO databases under the accession code GSE277382.
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