Toggle Main Menu Toggle Search

Open Access padlockePrints

Next generation brain health: transforming global research and public health to promote dementia prevention and risk reduction in young adult populations

Lookup NU author(s): Sarah Gregory, Dr Graciela Muniz Terrera, Professor Dame Louise Robinson, Dr Oliver Shannon, Dr Laura BooiORCiD

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Dementia prevention efforts can benefit from precision interventions that are delivered to the right populations at the right time; that is, when risk reduction potential is highest. Young adults (18-39 years) are a neglected population in dementia research and policy despite being highly exposed to known modifiable risk factors. It is unclear which risk and protective factors in young adulthood have the biggest impact on dementia outcomes, and how these associations differ across regions and groups. To address these uncertainties, the Next Generation Brain Health team convened a multidisciplinary expert group representing 15 nations across six continents. We identified high priority modifiable factors in young adulthood, and five key recommendations for promoting brain health, ranging from individual to policy levels. Increasing research and policy attention on brain health across the life course, inclusive of younger populations, is a critical next step in global dementia prevention efforts.


Publication metadata

Author(s): Farina FR, Bridgeman K, Gregory S, Crivelli L, Foote IF, Jutila OI, Kucikova L, Mariano LI, Nguyen KH, Thayanandan T, Akindejoye F, Butler J, Calandri IL, Cepukaityte G, Chiesa ST, Dawson WD, Deckers K, De la Cruz-Gongora V, Dounavi ME, Govia I, Guzmán-Vélez E, Heikal SA, Hill-Jarrett TG, Ibanez A, James BD, McGlinchey E, Mullin DS, Muniz-Terrera G, Pintado Caipa M, Qansuwa EM, Robinson L, Santuccione Chadha A, Shannon OM, Su L, Weidner W, Booi L

Publication type: Article

Publication status: Published

Journal: The Lancet Healthy Longevity

Year: 2024

Volume: 5

Issue: 12

Print publication date: 27/12/2024

Online publication date: 20/12/2024

Acceptance date: 11/11/2024

Date deposited: 19/11/2024

ISSN (electronic): 2666-7568

Publisher: The Lancet Publishing Group

URL: https://doi.org/10.1016/j.lanhl.2024.100665

DOI: 10.1016/j.lanhl.2024.100665

ePrints DOI: 10.57711/08fp-b218


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
Alzheimer’s Association (AARF-21-848281)
Alzheimer’s Research UK David Carr Fellowship (ARUK-RF2021B-006)
Alzheimer's Society UK (grant number: 612)
Applied Research Collaboration (ARC)
Dutch Medical Research Counciil
Dutch Ministry of Health, Wellbeing and Sport (grant number: 1051003210004)
Global Brain Health Institute, Trinity College Dublin (GBHI ALZ UK-22-863168)
National Institute for Health and Care Research
Northeast and North Cumbria (NENC) (NIHR200173)

Share