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Lookup NU author(s): Dr Ríona McArdle
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Background: Spatial orientation is required for independent mobility in society. Deficits in spatial 23 orientation can be an early symptom of Alzheimer’s disease and other dementias, and there is a need 24 for brief assessment tools to identify impairments. 25 Objective: The aim of this study was to evaluate the construct and known-group validity of our newly 26 developed Spatial Orientation Screening (SOS) questionnaire. 27 Methods: We included 132 patients with subjective cognitive decline (n=16), mild cognitive 28 impairment (n=32), or all-cause dementia (n=84) from a memory clinic and a reference group of 29 cognitively unimpaired older adults (n=108). The patients and their next-of-kin answered the self- and 30 proxy-rated versions of the 4-item SOS (0–8 points) and the 10-item Questionnaire of Everyday 31 Navigational Ability (QuENA, 0–30 points). The patients also performed the Floor Maze Test (FMT) 32 for performance-based spatial abilities. 33 Results: Mean ages (SD) of the patient and reference groups were 68.6 (±7.6) years and 73.7 (±6.7) 34 years, respectively. Construct validity between self-rated versions of the SOS and QuENA was 35 satisfactory with rs=0.66, between the proxy-rated versions rs=0.61, and between the proxy-reported 36 SOS and FMT rs=0.49 (all p<0.001). Known-group validity was also acceptable, with significantly 37 higher median (IQR) SOS self-reported scores in patients 1.0 (2.0) compared to the reference group 38 0.2 (0.5) points, (p<0.001). Informants reported more severe impairments compared to the patients’ 39 self-reports on both SOS and QuENA (both p<0.001). 40 Conclusion. The SOS had satisfactory validity for use as a screening instrument for assessment of 41 spatial orientation in memory clinic patients
Author(s): Tangen GG, Engedal K, Persson K, Selbaek G, Dakhil S, Mc Ardle R, Mjorud M, Rosvik J, Mengshoel AM, Knapskog AB
Publication type: Article
Publication status: Published
Journal: Journal of Alzheimer's Disease
Year: 2025
Pages: Epub ahead of print
Online publication date: 15/01/2025
Acceptance date: 05/11/2024
Date deposited: 11/11/2024
ISSN (print): 1387-2877
ISSN (electronic): 1875-8908
Publisher: IOS Press
URL: https://doi.org/10.1177/13872877241308877
DOI: 10.1177/13872877241308877
ePrints DOI: 10.57711/dt16-1k92
Data Access Statement: The full data set is, due to ethical restrictions, only available to the reader upon request to the corresponding author.
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