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From food waste to high value transformative healthcare solutions

Lookup NU author(s): Professor Katarina NovakovicORCiD

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Abstract

Chitosan, a linear, cationic copolymer, produced from the deacetylation of chitin found in fungal cell walls and crustaceans, with the latter being a major waste product of the fishing industry, is gaining momentum in efforts towards sustainable healthcare. Chitosan has been designated ‘Generally Recognized As Safe (GRAS)’ by the FDA and is approved for use in dietary supplements as well as applications in wound dressings and gels, but ambition goes well beyond this and includes formulations of intelligent stimuli responsive scaffolds for tissue engineering and advanced drug delivery systems. In this talk, we will present key findings from our studies ranging from chitosan purification and endotoxin removal [1], biodegradation and biocompatibility [1-3], to novel injectable, implantable [4] and recently developed transdermal formulations for drug delivery of both small drug molecules and biologics. 1. Effective Endotoxin Removal from Chitosan That Preserves Chemical Structure and Improves Compatibility with Immune Cells, Sophie L Reay, Emma L Jackson, Daniel Salthouse, Ana Marina Ferreira, Catharien MU Hilkens, Katarina Novakovic, Polymers, 2023. 2. In vitro evaluation of the biodegradability of chitosan–genipin hydrogels, Sophie L Reay, Emma L Jackson, Ana M Ferreira, Catharien MU Hilkens, Katarina Novakovic, Materials Advances, 2022. 3. Genipin‐crosslinked chitosan hydrogels: Preliminary evaluation of the in vitro biocompatibility and biodegradation, Nga TN Vo, Lei Huang, Henrique Lemos, Andrew L Mellor, Katarina Novakovic, Journal of Applied Polymer Science, 2021. 4. Poly (ethylene glycol)‐interpenetrated genipin‐crosslinked chitosan hydrogels: Structure, pH responsiveness, gelation kinetics, and rheology, Nga TN Vo, Lei Huang, Henrique Lemos, Andrew Mellor, Katarina Novakovic, Journal of Applied Polymer Science, 2020.


Publication metadata

Author(s): Novakovic K

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 24th Annual Conference on Material Science (YUCOMAT 2023)

Year of Conference: 2023

Print publication date: 04/09/2023

Online publication date: 04/09/2023

Acceptance date: 31/07/2023

Publisher: Materials Research Society of Serbia

URL: https://www.mrs-serbia.org.rs/index.php/24-yucomat-2023


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