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Lookup NU author(s): Dr Othman AlmusaimiORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Lasso peptides exhibit a range of bioactivities, including antiviral effects, inhibition of the glucagon receptor, blockade of the endothelin type B receptor, inhibition of myosin light chain kinase, and modulation of the atrial natriuretic factor, as well as notable antimicrobial properties. Intriguingly, lasso peptides exhibit remarkable proteolytic and thermal stability, addressing one of the key challenges that traditional peptides often face. The challenge in producing those valuable peptides remains the main hurdle in the way of producing larger quantities or even modifying them with more potent analogues. Genome mining and heterologous expression approaches have greatly facilitated the production of lasso peptides, moving beyond mere isolation techniques. This advancement not only allows for larger quantities but also enables the creation of additional analogues with improved stability and potency. This review aims to explore the unique bioactivities and stability of lasso peptides, along with recent advancements in genome mining and heterologous expression that address production challenges and open pathways for engineering potent analogues.
Author(s): Al Musaimi O
Publication type: Article
Publication status: Published
Journal: Peptides
Year: 2024
Volume: 182
Print publication date: 01/12/2024
Online publication date: 01/11/2024
Acceptance date: 29/10/2024
Date deposited: 20/11/2024
ISSN (print): 0196-9781
ISSN (electronic): 1873-5169
Publisher: Elsevier
URL: https://doi.org/10.1016/j.peptides.2024.171317
DOI: 10.1016/j.peptides.2024.171317
Data Access Statement: No data was used for the research described in the article.
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