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Lookup NU author(s): Dr Nusrat KhanORCiD, Professor Matthew Prina
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© 2024 The Author(s). Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Background: Little is known about the relationship between parkinsonism or Parkinson's disease (PD) and frailty in Latin America. Objective: The study aimed to determine the cross-sectional and prospective associations between parkinsonism and PD with frailty in a large multi-country cohort in Latin America. Frailty was assessed using three different models to explore which definitions are more appropriate to screen for frailty in a PD population. Methods: 12,865 older adults (aged ≥65 years) from the 10/66 population-based cohort study in six Latin American countries were analyzed. Logistic regression models assessed the cross-sectional association between parkinsonism/PD with baseline frailty. Individual country analyses were combined via fixed-effect meta-analysis. In non-frail participants who were followed up for 4 years, Cox proportional hazards regression models assessed the prospective association between parkinsonism/PD with incident frailty accounting for competing risk of mortality. Results: At baseline, the prevalence of parkinsonism and PD was 7% and 2%, respectively, and the prevalence of frailty varied across the three models with rates of 18% for frailty phenotype, 20% for frailty index and 30% for multidimensional frailty model. PD was associated with baseline and incident frailty after accounting for age, sex, and education: odds ratios and 95% confidence intervals (95% CI) for frailty were 2.49 (95% CIs 1.87–3.31), 2.42 (95% CIs 1.80–3.25), and 1.57 (95% CIs 1.16–2.21), and cause-specific hazard ratios were 1.66 (95% CIs 1.07–2.56), 1.78 (95% CIs 1.05–3.03), and 1.58 (95% CIs 0.91–2.74). Similar results were found for parkinsonism. Conclusion: Parkinsonism and PD were cross-sectionally and prospectively associated with frailty in Latin America. Routine screening for frailty in PD patients may aid earlier detection of those at greater risk of adverse outcomes.
Author(s): Kim DJ, Khan N, Llibre-Rodriguez JJ, Jiang M, Rodriguez-Salgado AM, Acosta I, Sosa AL, Acosta D, Jimenez-Velasquez IZ, Guerra M, Salas A, Sanchez ND, Lopez-Contreras R, Hesse H, Tanner C, Llibre-Guerra JJ, Prina M
Publication type: Article
Publication status: Published
Journal: Movement Disorders Clinical Practice
Year: 2024
Pages: epub ahead of print
Online publication date: 20/09/2024
Acceptance date: 04/09/2024
Date deposited: 02/10/2024
ISSN (electronic): 2330-1619
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/mdc3.14214
DOI: 10.1002/mdc3.14214
Data Access Statement: The data supporting the findings of this study are derived from the 10/66 Dementia Research Group’s population-based study. Data are available upon reasonable request to the 10/66 Dementia Research Group and subject to the approval of the respective data governance committees. Data requests can be submitted via the Alzheimer’s Disease Data Initiative (ADDI) platform
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