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Utilising accessible and reproducible neurological assessments in clinical studies: Insights from use of the Neurological Impairment Scale in the multi-centre COVID-CNS study

Lookup NU author(s): Dr Rhys ThomasORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024. Reproducible and standardised neurological assessment scales are important in quantifying research outcomes. These scales are often performed by non-neurologists and/or non-clinicians and must be robust, quantifiable, reproducible and comparable to a neurologist's assessment. COVID-CNS is a multi-centre study which utilised the Neurological Impairment Scale (NIS) as a core assessment tool in studying neurological outcomes following COVID-19 infection. We investigated the strengths and weaknesses of the NIS when used by non-neurology clinicians and non-clinicians, and compared performance to a structured neurological examination performed by a neurology clinician. Through our findings, we provide practical advice on how non-clinicians can be readily trained in conducting reproducible and standardised neurological assessments in a multi-centre study, as well as illustrating potential pitfalls of these tools.

Publication metadata

Author(s): Alam AM, Webb GW, Collie C, Mariathasan S, Huang Y, Hilton O, Shil R, Dodd KC, Lilleker JB, Smith CJ, Easton A, Tamborska A, Thomas RH, Davies NWS, Jenkins TM, Zandi M, Benjamin L, Ellul MA, Solomon T, Pollak TA, Nicholson T, Breen G, van Wamelen DJ, Wood NW, Michael BD

Publication type: Article

Publication status: Published

Journal: Clinical Medicine

Year: 2024

Volume: 24

Issue: 5

Online publication date: 06/09/2024

Acceptance date: 27/08/2024

Date deposited: 25/09/2024

ISSN (print): 1470-2118

ISSN (electronic): 1473-4893

Publisher: Elsevier BV

URL: https://doi.org/10.1016/j.clinme.2024.100241

DOI: 10.1016/j.clinme.2024.100241

PubMed id: 39244036

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