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Lookup NU author(s): Katie Gristwood, Dr Antony Antoniou, Dr Hannah Walden, Dr James KnightORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Royal Society of ChemistryA phenanthroline-type ligand containing an annealed 1,2,4-triazine ring was used to prepare novel Ir(iii) complexes 3 and 4. The complexes are non-luminescent but show luminogenic behaviour following the inverse electron demand Diels-Alder (IEDDA) reaction with bicyclononyne (BCN) derivatives. It was observed that the complexes react with BCN-C10 faster than the corresponding free ligands. The magnitude of this accelerating metal-coordination effect, however, is less profound than in previously reported Ir(iii) complexes of 1,2,4-triazines, in which the triazine was directly coordinated to the Ir(iii) metal centre. Nevertheless, luminogenic behaviour opens prospects for the use of such complexes in bioimaging applications, which was demonstrated by developing a convenient methodology using the “chemistry on the complex” concept for labelling antibodies with luminescent Ir(iii) complexes. The bioorthogonal reactivity of complex 4 was demonstrated by metabolically labelling live cells with BCN groups, followed by a luminogenic IEDDA reaction with the triazine iridium complex.
Author(s): Cooke L, Gristwood K, Adamson K, Sims MT, Deary ME, Bruce D, Antoniou AN, Walden HR, Knight JC, Antoine-Brunet T, Joly M, Goyard D, Lanoë P-H, Berthet N, Kozhevnikov VN
Publication type: Article
Publication status: Published
Journal: Dalton Transactions
Year: 2024
Volume: 53
Issue: 37
Print publication date: 07/10/2024
Online publication date: 28/08/2024
Acceptance date: 26/08/2024
Date deposited: 30/08/2024
ISSN (print): 1477-9226
ISSN (electronic): 1477-9234
Publisher: Royal Society of Chemistry
URL: https://doi.org/10.1039/d4dt01499e
DOI: 10.1039/d4dt01499e
Data Access Statement: The authors declare that the data supporting the findings of this study are available within the paper and its ESI files.† Should any raw data files be needed in another format they are available from the corresponding author upon reasonable request. https://pubs.rsc.org/en/content/articlelanding/2024/dt/d4dt01499e#fn1
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