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Lookup NU author(s): Dr Penny Lawton, Dr Laura YoungORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Journal © 2024.In vivo imaging using an adaptive optics scanning laser ophthalmoscope (AOSLO) is challenging, especially over extended periods. Pharmacological agents, administered as eye drops, are commonly used to dilate the pupil and paralyse accommodation, to improve image quality. However, they are contraindicated in some scenarios. Here, we evaluate the feasibility and reproducibility of performing AOSLO imaging without pharmacological pupil dilation over 1.5 hours with visual stimulation. Through statistical analysis and theoretical modelling using a dataset of retinal and pupil images collected from six healthy, young, near-emmetropic participants between the ages of 20–30 years, we validate that the retinal image quality does not change significantly with time in the experimental session (p = 0.33), and that pupil size has a strong effect on image quality but is not the only contributing factor.
Author(s): Cui J, Villamil M, Schneider AC, Lawton PF, Young LK, Booth MJ, Smithson HE
Publication type: Article
Publication status: Published
Journal: Biomedical Optics Express
Year: 2024
Volume: 15
Issue: 9
Pages: 4995-5008
Online publication date: 02/08/2024
Acceptance date: 22/07/2024
Date deposited: 17/09/2024
ISSN (electronic): 2156-7085
Publisher: Optica Publishing Group (formerly OSA)
URL: https://doi.org/10.1364/BOE.531808
DOI: 10.1364/BOE.531808
Data Access Statement: Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.
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