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Lookup NU author(s): Jonathan Horsley, Professor Yujiang WangORCiD, Callum Simpson, Vyte Janiukstyte, Karoline LeibergORCiD, Dr Beth LittleORCiD, Professor Peter TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The AuthorsStatus epilepticus (SE) carries risks of morbidity and mortality. Experimental studies have implicated the entorhinal cortex in prolonged seizures; however, studies in large human cohorts are limited. We hypothesised that individuals with temporal lobe epilepsy (TLE) and a history of SE would have more severe entorhinal atrophy compared to others with TLE and no history of SE. 357 individuals with drug resistant temporal lobe epilepsy (TLE) and 100 healthy controls were scanned on a 3T MRI. For all subjects, the cortex was segmented, parcellated, and the thickness calculated from the T1-weighted anatomical scan. Subcortical volumes were derived similarly. Cohen's d and Wilcoxon rank-sum tests respectively were used to capture effect sizes and significance. Individuals with TLE and SE had reduced entorhinal thickness compared to those with TLE and no history of SE. The entorhinal cortex was more atrophic ipsilaterally (d = 0.51, p < 0.001) than contralaterally (d = 0.37, p = 0.01). Reductions in ipsilateral entorhinal thickness were present in both left TLE (n = 22:176, d = 0.78, p < 0.001), and right TLE (n = 19:140, d = 0.31, p = 0.04), albeit with a smaller effect size in right TLE. Several other regions exhibited atrophy in individuals with TLE, but these did not relate to a history of SE. These findings suggest potential involvement or susceptibility of the entorhinal cortex in prolonged seizures.
Author(s): Horsley J, Wang Y, Simpson C, Janiukstyte V, Leiberg K, Little B, de Tisi J, Duncan J, Taylor PN
Publication type: Article
Publication status: Published
Journal: Epilepsy and Behavior
Year: 2024
Volume: 160
Print publication date: 01/11/2024
Online publication date: 06/09/2024
Acceptance date: 21/08/2024
Date deposited: 16/09/2024
ISSN (print): 1525-5050
ISSN (electronic): 1525-5069
Publisher: Academic Press Inc.
URL: https://doi.org/10.1016/j.yebeh.2024.110016
DOI: 10.1016/j.yebeh.2024.110016
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