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Lookup NU author(s): Dr Ben Talks, Michael Mather, Manisha Chahal, Professor Muzlifah Haniffa
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
The development and deployment of single-cell genomic technologies have driven a resolution revolution in our understanding of the immune system, providing unprecedented insight into the diversity of immune cells present throughout the body and their function in health and disease. Waldeyer's ring is the collective name for the lymphoid tissue aggregations of the upper aerodigestive tract, comprising the palatine, pharyngeal (adenoids), lingual, and tubal tonsils. These tonsils are the first immune sentinels encountered by ingested and inhaled antigens and are responsible for mounting the first wave of adaptive immune response. An effective mucosal immune response is critical to neutralizing infection in the upper airway and preventing systemic spread, and dysfunctional immune responses can result in ear, nose, and throat pathologies. This review uses Waldeyer's ring to demonstrate how single-cell technologies are being applied to advance our understanding of the immune system and highlight directions for future research.
Author(s): Talks BJ, Mather MW, Chahal M, Coates M, Clatworthy MR, Haniffa M
Publication type: Review
Publication status: Published
Journal: Annual Review of Genomics and Human Genetics
Year: 2024
Volume: 25
Pages: 161-182
Print publication date: 01/08/2024
Online publication date: 09/04/2024
Acceptance date: 02/04/2018
ISSN (print): 1527-8204
ISSN (electronic): 1545-293X
Publisher: Annual Reviews
URL: https://doi.org/10.1146/annurev-genom-120522-012938
DOI: 10.1146/annurev-genom-120522-012938
PubMed id: 38594932
