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Lookup NU author(s): Katie Gristwood, Dr Antony Antoniou, Dr Hannah Walden, Dr James KnightORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Phenanthroline-type ligand containing annealed 1,2,4-triazine ring was used to prepare novel Ir(III) complexes 3 and 4. The complexes are non-luminescent but show luminogenic behaviour following inverse electron demand Diels-Alder (IEDDA) reaction with bicyclononyne (BCN) derivatives. It was observed that the complexes react with BCN-C10 faster than the corresponding free ligands. The magnitude of this accelerating metal-coordination effect, however, is less profound that in previously reported Ir(III) complexes of 1,2,4-triazines in which the triazine was directly coordinated to Ir(III) metal centre. Nevertheless, luminogenic behaviour opens prospects for the use of such complexes in bioimaging applications, which was demonstrated by developing a convenient methodology using “chemistry on the complex” concept for labelling antibodies with luminescent Ir(III) complexes. Bioorthogonal reactivity of the complex 4 was demonstarted by metabolically labelling live cells with BCN groups followed by luminogenic IEDDA reaction with the triazine iridium complex.
Author(s): Cooke L, Gristwood K, Adamson K, Sims M, Deary M, Bruce D, Antoniou A, Walden H, Knight JC, Antoine-Brunet T, Joly M, Goyard D, Lanoë PH, Berthet N, Kozhevnikov V
Publication type: Article
Publication status: Published
Journal: Dalton Transactions
Year: 2024
Pages: Epub ahead of print
Online publication date: 28/08/2024
Acceptance date: 26/08/2024
Date deposited: 30/08/2024
ISSN (electronic): 1477-9234
Publisher: Royal Society of Chemistry
URL: https://doi.org/10.1039/D4DT01499E
DOI: doi.org/10.1039/D4DT01499E
Data Access Statement: The authors declare that the data supporting the findings of this study are available within the paper and its Supplementary Information files. Should any raw data files be needed in another format they are available from the corresponding author upon reasonable request.
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