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Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

Lookup NU author(s): Rhianna RowlandORCiD, Svitlana Korolchuk, Dr Marco Salamina, Dr Natalie TatumORCiD, Professor Martin NobleORCiD, Professor Jane Endicott

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Author(s): Rowland RJ, Korolchuk S, Salamina M, Tatum NJ, Ault JR, Hart S, Turkenburg JP, Blaza JN, Noble MEM, Endicott JA

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2024

Volume: 15

Issue: 1

Online publication date: 09/08/2024

Acceptance date: 22/07/2024

Date deposited: 04/09/2024

ISSN (electronic): 2041-1723

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/s41467-024-51135-w

DOI: 10.1038/s41467-024-51135-w

Data Access Statement: The cryo-EM map and model of the trimeric CDK2-cyclin A-CDC25A complex generated in this study have been deposited in the Protein Data Bank and the Electron Microscopy Data Bank with accession numbers PDB 8ROZ and EMD-19408. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE84 partner repository with the dataset identifier PXD050866. The Surface Plasmon Resonance and the Homogenous Time-Resolved Fluorescence data generated in this study are provided in the Supplementary Information. Source data are provided with this paper in the Source Data file. Accession codes mentioned in this study; PDB 1JST, PDB 1C25, PDB 1CWR, PDB 3OP3, PDB 2CJM, PDB 1B39, PDB 1BUH, PDB 1FQ1, PDB 8ROZ, EMD-19408, PDX050866.

PubMed id: 39122719

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