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Lookup NU author(s): Dr Othman AlmusaimiORCiD
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Peptides have been gaining ground in the pharmaceutical arena, with a total of 22 approvals over the last six years. These molecules are also present in antibody–drug conjugate constructs as linkers or payloads, or both. Solid-phase peptide synthesis (SPPS) is the method of choice for peptide synthesis. The introduction of an automatic synthesizer facilitated this methodology and helped in reducing the amounts of the required solvents. However, there are still concerns regarding the amounts, as well as the safety profiles, of the solvents involved in SPPS. Here, we discuss the work addressing the use of water as the greenest alternative to the common non-green solvents employed in various steps of the SPPS methodology. Various technologies were introduced which enabled the synthesis of di- and up to decapeptides in aqueous media with satisfactory yields and purities.
Author(s): Jaradat DMM, Al Musaimi O, Albericio F
Publication type: Article
Publication status: Published
Journal: Green Chemistry
Year: 2022
Volume: 24
Issue: 17
Pages: 6360-6372
Print publication date: 06/08/2022
Acceptance date: 02/08/2022
ISSN (electronic): 1463-9270
Publisher: Royal Society of Chemistry
URL: https://doi.org/10.1039/D2GC02319A
DOI: 10.1039/D2GC02319A
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