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Lookup NU author(s): Professor Philip Sloan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© 2024 The Author(s). Oral Diseases published by John Wiley & Sons Ltd. Objective: This study aimed to understand reasons for interobserver variability in the grading of oral epithelial dysplasia (OED) through a survey of pathologists to provide insight for improvements in the reliability and reproducibility of OED diagnoses. Methods: The study design included quantitative and qualitative methodology. A pre-validated 31-item questionnaire was distributed to general, head and neck, and oral and maxillofacial histopathology specialists worldwide. Results: A total of 132 pathologists participated and completed the questionnaire. Over two-thirds used the three-tier grading system for OED, while about a third used both binary and three-tier systems. Regular reporters of OED preferred the three-tier system and grading architectural features. Continuing education significantly aided recognition of architectural and cytological changes. Irregular epithelial stratification and drop-shaped rete ridges had the lowest prognostic value and recognition scores, while loss of epithelial cell cohesion had the highest. Most participants used clinical information and often sought a second opinion when grading OED. Conclusion: Our study has found that frequency of OED reporting and attendance of CME/CPD can play an important role in grading OED. Variations in the prognostic value of individual histological features and the use of clinical information may further contribute to interobserver variability.
Author(s): Ng GTE, Phang SC, Yu KS, Tiwari L, Khurram S, Sloan P, Kujan O
Publication type: Article
Publication status: Published
Journal: Oral Diseases
Year: 2024
Pages: ePub ahead of Print
Online publication date: 22/07/2024
Acceptance date: 09/07/2024
Date deposited: 29/07/2024
ISSN (print): 1354-523X
ISSN (electronic): 1601-0825
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1111/odi.15078
DOI: 10.1111/odi.15078
Data Access Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
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