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Lookup NU author(s): Dr James Miller
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2024 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.Background and purpose: Various electrodiagnostic criteria have been developed in Guillain–Barré syndrome (GBS). Their performance in a broad representation of GBS patients has not been evaluated. Motor conduction data from the International GBS Outcome Study (IGOS) cohort were used to compare two widely used criterion sets and relate these to diagnostic amyotrophic lateral sclerosis criteria. Methods: From the first 1500 patients in IGOS, nerve conduction studies from 1137 (75.8%) were available for the current study. These patients were classified according to nerve conduction studies criteria proposed by Hadden and Rajabally. Results: Of the 1137 studies, 68.3% (N = 777) were classified identically according to criteria by Hadden and Rajabally: 111 (9.8%) axonal, 366 (32.2%) demyelinating, 195 (17.2%) equivocal, 35 (3.1%) inexcitable and 70 (6.2%) normal. Thus, 360 studies (31.7%) were classified differently. The areas of differences were as follows: 155 studies (13.6%) classified as demyelinating by Hadden and axonal by Rajabally; 122 studies (10.7%) classified as demyelinating by Hadden and equivocal by Rajabally; and 75 studies (6.6%) classified as equivocal by Hadden and axonal by Rajabally. Due to more strictly defined cutoffs fewer patients fulfilled demyelinating criteria by Rajabally than by Hadden, making more patients eligible for axonal or equivocal classification by Rajabally. In 234 (68.6%) axonal studies by Rajabally the revised El Escorial (amyotrophic lateral sclerosis) criteria were fulfilled; in axonal cases by Hadden this was 1.8%. Conclusions and discussion: This study shows that electrodiagnosis in GBS is dependent on the criterion set utilized, both of which are based on expert opinion. Reappraisal of electrodiagnostic subtyping in GBS is warranted.
Author(s): Arends S, Drenthen J, de Koning L, van den Bergh P, Hadden RDM, Kuwabara S, Reisin RC, Shahrizaila N, Ajroud-Driss S, Antonini G, Attarian S, Balducci C, Bertorini T, Brannagan TH, Cavaletti G, Chao C-C, Chavada G, Dillmann K-U, Dimachkie MM, Galassi G, Gutierrez-Gutierrez G, Harbo T, Islam B, Islam Z, Katzberg H, Kusunoki S, Manganelli F, Miller JAL, Pardo J, Pereon Y, Rajabally YA, Sindrup S, Stettner M, Uncini A, Verhamme C, Vytopil M, Waheed W, Jacobs BC, Cornblath DR, Addington JM, Badrising UA, Barroso FA, Bateman K, Bella I, Benedetti L, van den Berg B, Bhavaraju-Sanka R, Briani C, Buermann J, Busby M, Butterworth S, Casasnovas C, Chen S, Claeys K, Conti E, Cosgrove JS, Dalakas M, van Damme P, Dardiotis E, Davidson A, Doets A, van Doorn P, Echaniz-Laguna A, Eftimov F, Faber KG, Fazio R, Feasby TE, Fehmi J, Fokke C, Fujioka T, Fulgenzi E, Garssen MPJ, Gijsbers CJ, Gilchrist JM, Gilhuis J, Goldstein JM, Gorson KC, Goyal N, Granit V, Gutmann L, Hartung H-P, Holt JKL, Hsieh S-T, Htut M, Hughes RAC, Jerico-Pascual I, Kaida K, Karafiath S, Khoshnoodi MA, Kiers L, Kleiweg RP, Kokubun N, Kolb NA, van Koningsveld R, van der Kooi AJ, Kramers H, Kuitwaard K, Kwan JY, Ladha SS, Lassen LL, Lawson VH, Lehmann H, Cejas LL, Leonhard SE, Luijten L, Lunn MPT, Manji H, Marfia GA, Infante CM, Martin-Aguilar L, Martinez-Hernandez E, Mataluni G, Mattiazzi M, McDermott C, Meekins G, Mohammad QD, Monges S, de la Tassa GM, Nascimbene C, Nobile-Orazio E, Nowak RJ, Osei-Bonsu M, Pelouto F, Pulley MT, Gutierrez LQ, Reddel SW, van der Ree T, Rinaldi S, Ripellino P, Roberts RC, Rojas-Marcos I, Roodbol J, Rudnicki SA, Sachs GM, Samijn JPA, Santoro L, Schenone A, Tous MJS, Sheikh KA, Silvestri NJ, Sundrup SH, Sommer C, Stein B, Stino AM, Thomma RCM, Twydell P, Varrato JD, Vermeij FH, Verschuuren J, Visser LH, Walgaard C, Wang Y, Willison HJ, Wirtz PW, van Woerkom M, Zivkovic SA
Publication type: Article
Publication status: Published
Journal: European Journal of Neurology
Year: 2024
Pages: epub ahead of print
Online publication date: 04/07/2024
Acceptance date: 29/04/2024
Date deposited: 17/07/2024
ISSN (print): 1351-5101
ISSN (electronic): 1468-1331
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/ene.16335
DOI: 10.1111/ene.16335
Data Access Statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
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