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Distinct feedforward and feedback pathways for cell-type specific attention effects

Lookup NU author(s): Dr Jochem van KempenORCiD, Dr Alwin GieselmannORCiD, Professor Alexander Thiele

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2024 The Author(s). Selective attention is thought to depend on enhanced firing activity in extrastriate areas. Theories suggest that this enhancement depends on selective inter-areal communication via gamma (30–80 Hz) phase-locking. To test this, we simultaneously recorded from different cell types and cortical layers of macaque V1 and V4. We find that while V1-V4 gamma phase-locking between local field potentials increases with attention, the V1 gamma rhythm does not engage V4 excitatory-neurons, but only fast-spiking interneurons in L4 of V4. By contrast, attention enhances V4 spike-rates in both excitatory and inhibitory cells, most strongly in L2/3. The rate increase in L2/3 of V4 precedes V1 in time. These findings suggest enhanced signal transmission with attention does not depend on inter-areal gamma phase-locking and show that the endogenous gamma rhythm has cell-type- and layer-specific effects on downstream target areas. Similar findings were made in the mouse visual system, based on opto-tagging of identified interneurons.


Publication metadata

Author(s): Spyropoulos G, Schneider M, van Kempen J, Gieselmann MA, Thiele A, Vinck M

Publication type: Article

Publication status: Published

Journal: Neuron

Year: 2024

Pages: ePub ahead of Print

Online publication date: 16/05/2024

Acceptance date: 17/04/2024

Date deposited: 11/06/2024

ISSN (print): 0896-6273

ISSN (electronic): 1097-4199

Publisher: Cell Press

URL: https://doi.org/10.1016/j.neuron.2024.04.020

DOI: 10.1016/j.neuron.2024.04.020

PubMed id: 38759641


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Funding

Funder referenceFunder name
093104Wellcome Trust
BMBF (Germany) Grant
Dutch Brain Interface Initiative
DFG VI Grants (908/5-1 and 908/7-1)
ERC Starting Grant
MR/K013785/1Medical Research Council (MRC)
MR/P013031/1Medical Research Council (MRC)
NWO VIDI Grant

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