Toggle Main Menu Toggle Search

Open Access padlockePrints

Dynamical and individualised approach of transcranial ultrasound neuromodulation effects in non-human primates

Lookup NU author(s): Professor Marcus Kaiser

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© The Author(s) 2024.Low-frequency transcranial ultrasound stimulation (TUS) allows to alter brain functioning with a high spatial resolution and to reach deep targets. However, the time-course of TUS effects remains largely unknown. We applied TUS on three brain targets for three different monkeys: the anterior medial prefrontal cortex, the supplementary motor area and the perigenual anterior cingulate cortex. For each, one resting-state fMRI was acquired between 30 and 150 min after TUS as well as one without stimulation (control). We captured seed-based brain connectivity changes dynamically and on an individual basis. We also assessed between individuals and between targets homogeneity and brain features that predicted TUS changes. We found that TUS prompts heterogenous functional connectivity alterations yet retain certain consistent changes; we identified 6 time-courses of changes including transient and long duration alterations; with a notable degree of accuracy we found that brain alterations could partially be predicted. Altogether, our results highlight that TUS induces heterogeneous functional connectivity alterations. On a more technical point, we also emphasize the need to consider brain changes over-time rather than just observed during a snapshot; to consider inter-individual variability since changes could be highly different from one individual to another.


Publication metadata

Author(s): Atkinson-Clement C, Alkhawashki M, Ross J, Gatica M, Zhang C, Sallet J, Kaiser M

Publication type: Article

Publication status: Published

Journal: Scientific Reports

Year: 2024

Volume: 14

Issue: 1

Online publication date: 24/05/2024

Acceptance date: 18/05/2024

Date deposited: 03/06/2024

ISSN (electronic): 2045-2322

Publisher: Nature Research

URL: https://doi.org/10.1038/s41598-024-62562-6

DOI: 10.1038/s41598-024-62562-6

Data Access Statement: The dataset and codes used in the current study are available from the corresponding author upon reasonable request.

PubMed id: 38789473


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
Engineering and Physical Sciences Research Council
EP/W004488/1
EP/X01925X/1
Guangci Professorship Program of Rui Jin Hospital
Shanghai Jiao Tong University

Share