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FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Lookup NU author(s): Professor Andrew FisherORCiD, Dr Bill ScottORCiD

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Author(s): Brevini T, Maes M, Webb GJ, John BV, Fuchs CD, Buescher G, Wang L, Griffiths C, Brown ML, Scott III WE, Pereyra-Gerber P, Gelson WTH, Brown S, Dillon S, Muraro D, Sharp J, Neary M, Box H, Tatham L, Stewart J, Curley P, Pertinez H, Forrest S, Mlcochova P, Varankar SS, Darvish-Damavandi M, Mulcahy VL, Kuc RE, Williams TL, Heslop JA, Rossetti D, Tysoe OC, Galanakis V, Vila-Gonzalez M, Crozier TWM, Bargehr J, Sinha S, Upponi SS, Fear C, Swift L, Saeb-Parsy K, Davies SE, Wester A, Hagstrom H, Melum E, Clements D, Humphreys P, Herriott J, Kijak E, Cox H, Bramwell C, Valentijn A, Illingworth CJR, Consortium UK-PBC, Dahman B, Bastaich DR, Ferreira RD, Marjot T, Barnes E, Moon AM, Barritt IV AS, Gupta RK, Baker S, Davenport AP, Corbett G, Gorgoulis VG, Buczacki SJA, Lee JH, Matheson NJ, Trauner M, Fisher AJ, Gibbs P, Butler AJ, Watson CJE, Mells GF, Dougan G, Owen A, Lohse AW, Vallier L, Sampaziotis F

Publication type: Article

Publication status: Published

Journal: Nature

Year: 2023

Volume: 615

Pages: 134-142

Online publication date: 05/12/2022

Acceptance date: 23/11/2022

Date deposited: 20/05/2024

ISSN (print): 0028-0836

ISSN (electronic): 1476-4687

Publisher: Springer

URL: https://doi.org/10.1038/s41586-022-05594-0

DOI: 10.1038/s41586-022-05594-0

Data Access Statement: scRNA-seq data are available on ArrayExpress under accession number E-MTAB-8495. Source data are provided with this paper.

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