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Lookup NU author(s): Dr Lisa Russell
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 the author(s), published by De Gruyter.We present a practical guide for analyzing the genetic aspects of lymphoblastic leukaemia/lymphoma according to the 5th edition of the World Health Organization (WHO) classification of haematolymphoid neoplasms (WHO-HAEM5) issued in 2024. The WHO-HAEM5 acknowledges the increasing importance of genetics in the diagnosis of lymphoid neoplasia. Classification is based on the established genetic subtypes according to cell lineage, with precursor cell neoplasms followed by mature malignancies. This guide describes those genetic abnormalities in acute precursor B- and T-cell neoplasms required for risk stratification, and for treatment, providing diagnostic algorithms under the headings of ‘essential’ and ‘desirable’ diagnostic criteria.
Author(s): Steinemann D, Dawidowska M, Russell LJ, Harrison CJ, Gohring G
Publication type: Article
Publication status: Published
Journal: Medizinische Genetik
Year: 2024
Volume: 36
Issue: 1
Pages: 39-45
Print publication date: 01/04/2024
Online publication date: 06/03/2024
Acceptance date: 02/04/2023
Date deposited: 25/03/2024
ISSN (print): 0936-5931
ISSN (electronic): 1863-5490
Publisher: Walter de Gruyter GmbH
URL: https://doi.org/10.1515/medgen-2024-2007
DOI: 10.1515/medgen-2024-2007
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