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From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers

Lookup NU author(s): Professor Jaume Bacardit

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Introduction: Osteoarthritis (OA) affects over 500 million people worldwide. OA patients are symptomatically treated, and current therapies exhibit marginal efficacy and frequently carry safety-risks associated with chronic use. No disease-modifying therapies have been approved to date leaving surgical joint replacement as a last resort. To enable effective patient care and successful drug development there is an urgent need to uncover the pathobiological drivers of OA and how these translate into disease endotypes. Endotypes provide a more precise and mechanistic definition of disease subgroups than observable phenotypes, and a panel of tissue- and pathology-specific biochemical markers may uncover treatable endotypes of OA. Areas covered: We have searched PubMed for full-text articles written in English to provide an in-depth narrative review of a panel of validated biochemical markers utilized for endotyping of OA and their association to key OA pathologies. Expert opinion: As utilized in IMI-APPROACH and validated in OAI-FNIH, a panel of biochemical markers may uncover disease subgroups and facilitate the enrichment of treatable molecular endotypes for recruitment in therapeutic clinical trials. Understanding the link between biochemical markers and patient-reported outcomes and treatable endotypes that may respond to given therapies will pave the way for new drug development in OA.


Publication metadata

Author(s): Hannani MT, Thudium CS, Karsdal MA, Ladel C, Mobasheri A, Uebelhoer M, Larkin J, Bacardit J, Struglics A, Bay-Jensen A-C

Publication type: Review

Publication status: Published

Journal: Expert Review of Molecular Diagnostics

Year: 2024

Volume: 24

Issue: 1-2

Pages: 23-38

Online publication date: 14/02/2024

Acceptance date: 02/02/2024

ISSN (print): 1473-7159

ISSN (electronic): 1744-8352

Publisher: Taylor and Francis Ltd.

URL: https://doi.org/10.1080/14737159.2024.2315282

DOI: 10.1080/14737159.2024.2315282

PubMed id: 38353446


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