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Lookup NU author(s): Dr Grazia Pompei, Nandine Ganzorig, Professor Vijay KunadianORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© The Author(s), 2024.Vasospastic angina (VSA) refers to chest pain experienced as a consequence of myocardial ischaemia caused by epicardial coronary spasm, a sudden narrowing of the vessels responsible for an inadequate supply of blood and oxygen. Coronary artery spasm is a heterogeneous phenomenon that can occur in patients with non-obstructive coronary arteries and obstructive coronary artery disease, with transient spasm causing chest pain and persistent spasm potentially leading to acute myocardial infarction (MI). VSA was originally described as Prinzmetal angina or variant angina, classically presenting at rest, unlike most cases of angina (though in some patients, vasospasm may be triggered by exertion, emotional, mental or physical stress), and associated with transient electrocardiographic changes (transient ST-segment elevation, depression and/or T-wave changes). Ischaemia with non-obstructive coronary arteries (INOCA) is not a benign condition, as patients are at elevated risk of cardiovascular events including acute coronary syndrome, hospitalization due to heart failure, stroke and repeat cardiovascular procedures. INOCA patients also experience impaired quality of life and associated increased healthcare costs. VSA, an endotype of INOCA, is associated with major adverse events, including sudden cardiac death, acute MI and syncope, necessitating the study of the most effective treatment options currently available. The present literature review aims to summarize current data relating to the diagnosis and management of VSA and provide details on the sequence that treatment should follow.
Author(s): Jenkins K, Pompei G, Ganzorig N, Brown S, Beltrame J, Kunadian V
Publication type: Review
Publication status: Published
Journal: Therapeutic Advances in Cardiovascular Disease
Year: 2024
Volume: 18
Online publication date: 11/02/2024
Acceptance date: 17/01/2024
ISSN (print): 1753-9447
ISSN (electronic): 1753-9455
Publisher: SAGE Publications Ltd
URL: https://doi.org/10.1177/17539447241230400
DOI: 10.1177/17539447241230400
PubMed id: 38343041
