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Lookup NU author(s): Dr Lisa AlcockORCiD, Jane Newman
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023, The Author(s).With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials. This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes.
Author(s): Ilg W, Milne S, Schmitz-Hubsch T, Alcock L, Beichert L, Bertini E, Mohamed Ibrahim N, Dawes H, Gomez CM, Hanagasi H, Kinnunen KM, Minnerop M, Nemeth AH, Newman J, Ng YS, Rentz C, Samanci B, Shah VV, Summa S, Vasco G, McNames J, Horak FB
Publication type: Review
Publication status: Published
Journal: Cerebellum
Year: 2023
Volume: 23
Pages: 1566-1592
Online publication date: 13/11/2023
Acceptance date: 20/10/2023
ISSN (print): 1473-4222
ISSN (electronic): 1473-4230
Publisher: Springer
URL: https://doi.org/10.1007/s12311-023-01625-2
DOI: 10.1007/s12311-023-01625-2
