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Plasma cortisol linked gene networks in hepatic and adipose tissues implicate corticosteroid binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

Lookup NU author(s): Professor Brian WalkerORCiD

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Author(s): Bankier S, Wang L, Crawford A, Morgan RA, Ruusalepp A, Andrew R, Bjorkegren JLM, Walker BR, Michoel T

Publication type: Article

Publication status: Published

Journal: Frontiers Endocrinology

Year: 2023

Volume: 14

Online publication date: 06/09/2023

Acceptance date: 14/07/2023

Date deposited: 28/07/2023

ISSN (electronic): 1664-2392

Publisher: Frontiers Research Foundation

URL: https://doi.org/10.3389/fendo.2023.1186252

DOI: 10.3389/fendo.2023.1186252

Data Access Statement: All code used in the analyses presented in this study are available at the following repository: https://github.com/sbankier/ cortisol_networks/tree/main. Data from the Stockholm Tartu Atherosclerosis Reverse Networks Engineering Task study (STARNET) are available through a database of Genotypes and Phenotypes (dbGaP) application (accession no. phs001203.v2.p1). Gene expression data from The Stockholm Atherosclerosis Gene Expression study (STAGE) and the Metabolic Syndrome in Man study (METSIM) are available publicly at GEO (accession no. GSE70353 and GSE40231, respectively). The summary statistics from the CORNET GWAMA are available at Edinburgh DataShare: https://datashare.ed.ac.uk/handle/10283/3836.

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