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Lookup NU author(s): Professor Andrew Trevelyan
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. A critical question regarding how focal seizures start is whether we can identify particular cell classes that drive the pathological process. This was the topic for debate at the recent International Conference for Technology and Analysis of Seizures (ICTALS) meeting (July 2022, Bern, CH) that we summarize here. The debate has been fueled in recent times by the introduction of powerful new ways to manipulate subpopulations of cells in relative isolation, mostly using optogenetics. The motivation for resolving the debate is to identify novel targets for therapeutic interventions through a deeper understanding of the etiology of seizures.
Author(s): Wenzel M, Huberfeld G, Grayden DB, de Curtis M, Trevelyan AJ
Publication type: Article
Publication status: Published
Journal: Epilepsia
Year: 2023
Volume: 64
Issue: S3
Pages: S37-S48
Online publication date: 15/05/2023
Acceptance date: 12/05/2023
Date deposited: 28/06/2023
ISSN (print): 0013-9580
ISSN (electronic): 1528-1167
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1111/epi.17650
DOI: 10.1111/epi.17650
PubMed id: 37183507
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