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Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia

Lookup NU author(s): Dr Rachael LawsonORCiD

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Abstract

Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the PICC Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n=837 and PDD n=157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD [-1.8 (CI 95% -2.3;-1.3) vs -1.9 (CI 95% -2.6;-1.2) (p=0.74)]. MDS-UPDRS part III showed nearly identical annual changes [DLB 4.8 (CI 95% 2.1; 7.5)] [PDD 4.8 (CI 95% 2.7; 6.9), (p=0.98)]. Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.

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Author(s): Gonzalez MC, Tovar-Rios DA, Alves G, Dalen I, Williams-Gray CH, Camacho M, Forsgren L, Bäckström D, Lawson RA, Macleod AD, Counsell CE, Paquet C, DeLena C, DAntonio F, Pilotto A, Padovani A, Blanc F, Falup-Pecurariu C, Lewis S, Rejdak K, Papuc A, Hort J, Nedelska Z, O'Brien J, Bonanni L, Marquié M, Abdelnour C, Alcolea D, Beyer K, Aarsland D, Maple-Grødem J

Publication type: Article

Publication status: Published

Journal: Movement Disorders Clinical Practice

Year: 2023

Volume: 10

Issue: 6

Pages: 980-986

Print publication date: 01/06/2023

Online publication date: 18/04/2023

Acceptance date: 29/03/2023

Date deposited: 06/04/2023

ISSN (print): 2330-1619

Publisher: Wiley

URL: https://doi.org/10.1002/mdc3.13752

DOI: 10.1002/mdc3.13752

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