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Lookup NU author(s): Dr Paul Donaghy, Dr Dag Aarsland, Dr Joseph Kane, Professor Alan ThomasORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
INTRODUCTION: Operationalised research criteria for mild cognitive impairment with Lewy bodies(MCI-LB) were published in 2020. The aim of this systematic review and meta-analysis was to reviewthe evidence for the diagnostic clinical features and biomarkers in MCI-LB set out in the criteria. METHODS: MEDLINE, PubMed and Embase were searched on 9/28/22 for relevant articles. Articleswere included if they presented original data reporting the rates of diagnostic features in MCI-LB. RESULTS: 57 articles were included. The meta-analysis supported the inclusion of the current clinical features in the diagnostic criteria. Evidence for striatal dopaminergic imaging and metaiodobenzylguanidinecardiac scintigraphy, though limited, supports their inclusion. Quantitative EEGand fluorodeoxyglucose PET show promise as diagnostic biomarkers. DISCUSSION: The available evidence largely supports the current diagnostic criteria for MCI-LB. Further evidence will help refine the diagnostic criteria and understand how best to apply them in clinical practice and research.
Author(s): Donaghy PC, Carrarini C, Ferreira D, Habich A, Aarsland D, Babiloni C, Bayram E, Kane JPM, Lewis SJG, Pilotto A, Thomas AJ, Bonanni L
Publication type: Article
Publication status: Published
Journal: Alzheimer's and Dementia
Year: 2023
Volume: 19
Issue: 7
Pages: 3186-3202
Print publication date: 01/07/2023
Online publication date: 24/04/2023
Acceptance date: 23/03/2023
Date deposited: 26/04/2023
ISSN (print): 1552-5260
ISSN (electronic): 1552-5279
Publisher: John Wiley & Sons, Inc.
URL: https://doi.org/10.1002/alz.13105
DOI: 10.1002/alz.13105
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