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Lookup NU author(s): Professor Giorgio TascaORCiD
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© 2016 International Society of Neuropathology.Amyotrophic Lateral Sclerosis (ALS) is characterized by the degeneration of upper and lower motor neurons. Clinical heterogeneity is a well-recognized feature of the disease as age of onset, site of onset and the duration of the disease can vary greatly among patients. A number of genes have been identified and associated to familial and sporadic forms of ALS but the majority of cases remains still unexplained. Recent breakthrough discoveries have demonstrated that clinical manifestations associated with ALS-related genes are not circumscribed to motor neurons involvement. In this view, ALS appears to be linked to different conditions over a continuum or spectrum in which overlapping phenotypes may be identified. In this review, we aim to examine the increasing number of spectra, including ALS/Frontotemporal Dementia and ALS/Myopathies spectra. Considering all these neurodegenerative disorders as different phenotypes of the same spectrum can help to identify common pathological pathways and consequently new therapeutic targets in these incurable diseases.
Author(s): Sabatelli M, Marangi G, Conte A, Tasca G, Zollino M, Lattante S
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Mini-Symposium: Amyotrophic Lateral Sclerosis: An Update on its complexity
Year of Conference: 2016
Pages: 266-275
Print publication date: 22/03/2016
Online publication date: 18/01/2016
Acceptance date: 14/01/2016
ISSN: 1750-3639
Publisher: Blackwell Publishing Ltd
URL: https://doi.org/10.1111/bpa.12354
DOI: 10.1111/bpa.12354
PubMed id: 26780671
Series Title: Brain Pathology
