Toggle Main Menu Toggle Search

Open Access padlockePrints

Cellular Senescence and Ageing

Lookup NU author(s): Becca Reed, Dr Satomi Miwa

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.Cellular senescence has become a subject of great interest within the ageing research field over the last 60 years, from the first observation in vitro by Leonard Hayflick and Paul Moorhead in 1961, to novel findings of phenotypic sub-types and senescence-like phenotype in post-mitotic cells. It has essential roles in wound healing, tumour suppression and the very first stages of human development, while causing widespread damage and dysfunction with age leading to a raft of age-related diseases. This chapter discusses these roles and their interlinking pathways, and how the observed accumulation of senescent cells with age has initiated a whole new field of ageing research, covering pathologies in the heart, liver, kidneys, muscles, brain and bone. This chapter will also examine how senescent cell accumulation presents in these different tissues, along with their roles in disease development. Finally, there is much focus on developing treatments for senescent cell accumulation in advanced age as a method of alleviating age-related disease. We will discuss here the various senolytic and senostatic treatment approaches and their successes and limitations, and the innovative new strategies being developed to address the differing effects of cellular senescence in ageing and disease.


Publication metadata

Author(s): Reed R, Miwa S

Editor(s): J. Robin Harris and Viktor I. Korolchuk

Publication type: Book Chapter

Publication status: Published

Book Title: Biochemistry and Cell Biology of Ageing: Part III Biomedical Science

Year: 2023

Volume: 102

Pages: 139-173

Print publication date: 06/01/2023

Online publication date: 05/01/2023

Acceptance date: 02/04/2018

Series Title: Subcellular Biochemistry

Publisher: Springer

Place Published: Cham

URL: https://doi.org/10.1007/978-3-031-21410-3_7

DOI: 10.1007/978-3-031-21410-3_7

PubMed id: 36600133

Library holdings: Search Newcastle University Library for this item

ISBN: 9783031214097


Share